MT-2

Melanotan II (MT-2) is a synthetic analogue of α-Melanocyte Stimulating Hormone (α-MSH), engineered for enhanced potency and metabolic stability compared to the native peptide. It acts as a non-selective melanocortin receptor agonist, with research spanning pigmentation biology, sexual function, appetite regulation, and energy homeostasis.

Mechanism MT-2 binds to melanocortin receptors (MC1R, MC3R, MC4R, MC5R), triggering downstream cAMP signaling pathways. MC1R activation drives melanogenesis and eumelanin production, while MC4R activation is central to its research in appetite suppression and sexual arousal pathways.

Research Areas: Melanogenesis & skin pigmentation · Sexual function & libido · Appetite suppression & energy regulation · Inflammation modulation · Neuroprotective signaling

For research use only. Not for human consumption.